Higher Ratios of Hyaluronic Acid Enhance Chondrogenic Differentiation of Human MSCs in a Hyaluronic Acid–Gelatin Composite Scaffold

Higher Ratios of Hyaluronic Acid Enhance Chondrogenic Differentiation of Human MSCs in a Hyaluronic Acid–Gelatin Composite Scaffold

Mesenchymal stem cells (MSCs) seeded on specific carrier materials are a promising source for the repair of traumatic cartilage injuries. The best supportive carrier material has not yet been determined. As natural components of cartilage's extracellular matrix, hyaluronic acid and collagen are the focus of biomaterial research. In order to optimize chondrogenic support, we investigated three d...

Synthesis of Polyurethane/Hyaluronic acid/Royal Jelly Electrospun Scaffold and Evaluating its Properties for Wound Healing

Background and purpose: Studies showed that biocompatible and biodegradable materials in tissue engineering can be used to heal wounds. The aim of this study was to fabricate polyurethane/royal jelly/hyaluronic acid scaffold with suitable biological properties for wound healing using electrospinning method. Materials and methods: In this applied experimental study, to make a nanofiber scaffold...

The Effect of Hypoxic Pre-Culture on Chondrogenic Differentiation of Human Amniotic Fluid-Derived Stem Cells in a Collagen-Hyaluronic Acid Scaffold

PKCa Agonists Enhance the Protective Effect of Hyaluronic Acid on Nitric Oxide-Induced Apoptosis of Articular Chondrocytes in Vitro

  Objective(s): Protein kinase C (PKCα) is involved in modulating articular chondrocytes apoptosis induced by nitric oxide (NO). Hyaluronic acid (HA) inhibits nitric oxide-induced apoptosis of articular chondrocytes by protecting PKCα, but the mechanism remains unclear. The present study was performed to investigate the effects and mechanisms of PKCα regulate protective effect of hya...

Viability and differentiation of neural precursors on hyaluronic acid hydrogel scaffold.

The traditional notion that injured neurons are unable to regenerate in the adult mammalian brain and spinal cord has long been a concern. This view has led to methodology designed to overcome this problem, most recently by advancements in tissue engineering. Here, neural precursor cells (NPCs) and the Nogo receptor antibody (NgR-Ab) or poly-L-lysine (PLL) were tested in concert with hyaluronic...